Heterogeneity maintenance in glioblastoma: a social network.
Heterogeneity maintenance in glioblastoma: a social network.
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DOI：
10.1158/0008-5472.can-11-0153
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发表时间：
2011-06-15
期刊：
影响因子：
11.2
通讯作者：
Furnari FB
中科院分区：
文献类型：
--
作者：
Bonavia R;Inda MM;Cavenee WK;Furnari FB
多形性胶质母细胞瘤（GBM）是成人最常见的颅内肿瘤，其特征在于在细胞和分子水平上具有广泛的异质性。这种潜在的特征不可避免地出现在几乎所有的癌症中，并且对恶性肿瘤的一般结果具有重要意义，因为它混淆了我们对疾病的理解，并且还本质上有助于肿瘤的侵袭性，并且对有效疗法的设计构成障碍。经典观点认为异质性是肿瘤“遗传混乱”的结果，以及更现代的癌症干细胞（CSC）假说倾向于将单个细胞群体确定为治疗靶点：在第一种情况下，随着时间的推移，占主导地位的克隆，后者是CSC。然而，越来越多的证据表明，不同的肿瘤细胞群可能不是简单的旁观者。相反，它们可以在彼此之间以及与肿瘤微环境之间建立复杂的相互作用网络，最终加强肿瘤生长并增加逃避治疗的机会。这些不同的，但互补的想法的起源和维持肿瘤异质性及其重要性GBM将在这里进行审查。
Glioblastoma multiforme (GBM), the most common intracranial tumor in adults, is characterized by extensive heterogeneity at the cellular and molecular levels. This insidious feature arises inevitably in almost all cancers and has great significance for the general outcome of the malignancy because it confounds our understanding of the disease and also intrinsically contributes to the tumor’s aggressiveness and poses an obstacle to the design of effective therapies. The classical view that heterogeneity arises as the result of a tumor’s “genetic chaos”, as well as the more contemporary cancer stem cell (CSC) hypothesis tend to identify a single cell population as the therapeutic target: the prevailing clone over time in the first case and the CSC in the latter. However, there is growing evidence that the different tumor cell populations may not be simple bystanders. Rather, they can establish a complex network of interactions between each other and with the tumor microenvironment that eventually strengthens tumor growth and increases chances to escape therapy. These differing but complementary ideas about the origin and maintenance of tumor heterogeneity and its importance in GBM will be reviewed here.