Size and Shell Effects on the Photoacoustic and Luminescence Properties of Dual Modal Rare-Earth-Doped Nanoparticles for Infrared Photoacoustic Imaging
Size and Shell Effects on the Photoacoustic and Luminescence Properties of Dual Modal Rare-Earth-Doped Nanoparticles for Infrared Photoacoustic Imaging
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DOI：
10.1021/acsbiomaterials.6b00012
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发表时间：
2016-05-01
影响因子：
5.8
通讯作者：
Tan, Mei Chee
中科院分区：
文献类型：
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作者：
Sheng, Yang;Liao, Lun-De;Tan, Mei Chee
稀土（镱和铒）掺杂纳米颗粒（REDNPs）是近年来发展起来的一种具有高分辨率和高对比度的深部组织发光和光声（PA）成像的优良探针。在这里，我们报告的第一个研究的尺寸和表面效应的红外PA成像的双模REDNPs。我们发现，通过增加尺寸和涂覆无机壳（未掺杂的NaYF4或二氧化硅），REDNPs产生的PA信号幅度增加。我们还发现，涂层材料的选择是至关重要的，因为未掺杂的NaYF4壳能够同时增强PA信号幅度（高达30%）和红外发射（19倍）。PA信号幅度和红外发射的同时增强是由于声子模式的增加和表面效应的减少。获得的体内PA图像表明，除了是优异的发光探针之外，REDNPs还作为成功的PA造影剂来可视化啮齿动物皮层血管。
Infrared-emitting rare-earth (ytterbium and erbium) doped nanoparticles (REDNPs) have recently emerged as an excellent probe for both deep tissue luminescence and photoacoustic (PA) imaging with high resolutions and contrast. Here we report on the first study of the size and surface effects of the infrared PA imaging of dual modal REDNPs. We show that the PA signal amplitude generated by REDNPs is increased by increasing the size and coating the inorganic shell (undoped NaYF4 or silica). We have also discovered that the choice of the coating material is critical as undoped NaYF4 shell was able to enhance PA signal amplitude (by up to similar to 30%) and infrared emission (19 times) simultaneously. The simultaneous enhancement of PA signal amplitude and infrared emission was due to increased phonon modes and reduced surface effects. The in vivo PA images obtained demonstrated that in addition to being excellent luminescent probes, the REDNPs also performed as successful PA contrast agents to visualize rodent cortical blood vessels.