Enantioselective hydrogenation of methyl pyruvate over polymer-stabilized and supported iridium clusters
Enantioselective hydrogenation of methyl pyruvate over polymer-stabilized and supported iridium clusters
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DOI：
10.1016/s1381-1169(99)00129-6
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发表时间：
1999-11
影响因子：
--
通讯作者：
X. Zuo;Hanfan Liu;C. Yue
中科院分区：
文献类型：
--
作者：
X. Zuo;Hanfan Liu;C. Yue
The enantioselective hydrogenation of methyl pyruvate was studied over finely dispersed polyvinylpyrrolidone-stabilized iridium (PVP-Ir) and the corresponding alumina-supported iridium cluster (Al2O3-Ir) modified with cinchonidine. It was found that the modifier, apart from inducing enantioselectivity, has a considerable rate-promoting effect on this reaction with the average rate increased by a factor of 2–3.5 over both the two kinds of catalysts. Favorable reaction parameters were 283 K, 4.0 MPa and alcohols or acetic acid as solvents. Similar to what had been reported in Pt/cinchona system, the highest value of the enantiomeric excess (34.1%) was obtained in acetic acid, accompanied by a marked enhancement of the reaction rate.
