Enhancers navigate the three-dimensional genome to direct cell fate decisions.
Enhancers navigate the three-dimensional genome to direct cell fate decisions.
复制标题
增强子导航三维基因组以指导细胞命运决定。
DOI：
10.1016/j.sbi.2021.06.005
复制
发表时间：
2021
影响因子：
6.8
通讯作者：
Dean,Ann
中科院分区：
文献类型：
--
作者：
Kim,Juhyun;Dean,Ann
转录增强子的活性和选择性决定了基因表达模式，使受精卵能够成为复杂的生物体。增强子如何传递调控信息是生物学中的一个核心难题。在这里，我们讨论了最近的进展提供了快速发展的技术在理解增强子-启动子相互作用的背景下，整个核基因组组织。
The activity and selectivity of transcriptional enhancers determine gene expression patterns that enable a zygote to become a complex organism. How enhancers convey regulatory information is a central conundrum in biology. Here, we discuss recent progress provided by rapidly evolving technologies in understanding enhancer–promoter interactions in the context of overall nuclear genome organization.