State-dependent and cell type-specific temporal processing in auditory thalamocortical circuit.
State-dependent and cell type-specific temporal processing in auditory thalamocortical circuit.
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DOI：
10.1038/srep18873
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发表时间：
2016-01-05
影响因子：
4.6
通讯作者：
Sakata S
中科院分区：
文献类型：
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作者：
Sakata S
皮质回路中持续的自发活动定义了皮质状态，但皮质状态如何在皮质层中形成感觉处理以及皮质中出现什么类型的反应特性仍然不清楚。在电刺激基底前脑（BF）的同时，记录了麻醉大鼠听皮层（AC）和内侧膝状体（MGB）的神经活动，研究了听觉丘脑皮层回路的状态依赖性自发活动和诱发活动。BF刺激诱导了短暂的去同步状态，浅层中的伽马频率下的放电较稀疏且功率增加。在这种desperzized状态下，在AC和MGB的发病反应变异性的减少是伴随着细胞类型的特定的射击，皮质宽尖峰细胞的反应减少，但皮质窄尖峰细胞的反应增加。这种发病反应，其次是不同的时间演变AC，更快的反弹发射在颗粒下层。这种时间配置文件与改善处理的时间结构的刺激在不同程度上跨AC层，但不是在MGB。因此，减少在deserminized状态下的反应变异性可以看出subcortically，而改善的时间调谐出现在整个AC层，强调的重要性，状态依赖性皮层内处理听力。
Ongoing spontaneous activity in cortical circuits defines cortical states, but it still remains unclear how cortical states shape sensory processing across cortical laminae and what type of response properties emerge in the cortex. Recording neural activity from the auditory cortex (AC) and medial geniculate body (MGB) simultaneously with electrical stimulations of the basal forebrain (BF) in urethane-anesthetized rats, we investigated state-dependent spontaneous and auditory-evoked activities in the auditory thalamocortical circuit. BF stimulation induced a short-lasting desynchronized state, with sparser firing and increased power at gamma frequency in superficial layers. In this desynchronized state, the reduction in onset response variability in both AC and MGB was accompanied by cell type-specific firing, with decreased responses of cortical broad spiking cells, but increased responses of cortical narrow spiking cells. This onset response was followed by distinct temporal evolution in AC, with quicker rebound firing in infragranular layers. This temporal profile was associated with improved processing of temporally structured stimuli across AC layers to varying degrees, but not in MGB. Thus, the reduction in response variability during the desynchronized state can be seen subcortically whereas the improvement of temporal tuning emerges across AC layers, emphasizing the importance of state-dependent intracortical processing in hearing.