Micelles self-assembled from thermoresponsive 2-hydroxy-3-butoxypropyl starches for drug delivery
Micelles self-assembled from thermoresponsive 2-hydroxy-3-butoxypropyl starches for drug delivery
复制标题
由热响应性 2-羟基-3-丁氧基丙基淀粉自组装的胶束用于药物输送
DOI：
10.1016/j.carbpol.2011.09.028
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发表时间：
2012-01-15
影响因子：
11.2
通讯作者：
Zhang, Shufen
中科院分区：
文献类型：
--
作者：
Ju, Benzhi;Yan, Dongmao;Zhang, Shufen
一类新的热敏聚合物。以丁缩水甘油醚为疏水试剂，通过改变淀粉的亲疏平衡，合成了2-羟基-3-丁氧基丙基淀粉（HBPS）。在4.5 ~ 32.5℃范围内，通过改变疏水基团的摩尔取代（MS），可以调节HBPS的较低临界溶液温度（LCSTs）。在水中，HBPS可以在LCST以下自组装成胶束，而胶束在LCST以上变形并聚集成更极性和更大的物体。载药HBPS胶束表现出热响应性控释，即在LCST以上药物释放显著加速。(C) 2011 Elsevier Ltd.版权所有。
A new class of thermoresponsive polymers. 2-hydroxy-3-butoxypropyl starches (HBPS), was synthesized by changing the hydrophobic-hydrophilic balance of starch using butyl glycidyl ether as hydrophobic reagent. The lower critical solution temperatures (LCSTs) of HBPS can be adjusted by varying the molar substitution (MS) of hydrophobic groups in the range of 4.5-32.5 degrees C. In water, HBPS can self-assemble into micelles below the LCST, and the micelles are deformed and aggregate into more polar and larger objects above the LCST. The drug loading HBPS micelles showed thermoresponsive controlled release, namely, the drug release is accelerated dramatically above the LCST. (C) 2011 Elsevier Ltd. All rights reserved.