Dynamic MR lymphangiography and carbon dye for sentinel lymph node detection: A solution for sentinel lymph node biopsy in mucosal head and neck cancer
Dynamic MR lymphangiography and carbon dye for sentinel lymph node detection: A solution for sentinel lymph node biopsy in mucosal head and neck cancer
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DOI：
10.1002/hed.20173
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发表时间：
2005-04-01
影响因子：
2.9
通讯作者：
Thliveris, J
中科院分区：
文献类型：
--
作者：
Nason, RW;Torchia, MG;Thliveris, J
背景。前哨淋巴结活检在头颈部鳞状细胞癌中的实际应用受到蓝色染料的时间敏感性、缺乏空间分辨率和放射性胶体非特异性淋巴结增强的限制。本研究评估使用磁共振（MR）淋巴管造影和碳染料标记来规避这些限制。将钆/碳染料混合物注射到成年猪的舌头和喉咙（n = 4）。术中用异硫丹蓝染色进行MR淋巴造影。4例在注射后60分钟，8例在注射后7天进行前哨淋巴结活检和完全淋巴结清扫。该技术在所有12个节点盆地都取得了成功。前哨淋巴结在立即和延迟清扫时被染成黑色。MR淋巴管造影通过单一的检查提供前哨淋巴结的时间和解剖定位。碳染料是一种敏感和持久的视觉标记物，mri靶向前哨淋巴结。(c) 2005 Wiley期刊有限公司
Background. The practical application of sentinel lymph node biopsy in squamous cell carcinoma of the head and neck is restricted by the time sensitivity of blue dye and lack of spatial resolution and nonspecific node enhancement with radiocolloid. This study evaluates the use of magnetic resonance (MR) lymphangiography and carbon dye labeling to circumvent these limitations.Methods. Gadomer/carbon dye mixture was injected into the tongue and stifle of adult swine (n = 4). MR lymphatic mapping was followed by intraoperative mapping with isosulfan blue dye. Sentinel lymph node biopsy and completion node dissection were performed 60 minutes after injection in four nodal basins and at 7 days after injection in eight.Results. The technique was successful in all 12 nodal basins. The sentinel lymph nodes were stained black at the time of the immediate and delayed dissections.Conclusions. MR lymphangiography provides temporal and anatomic localization of the sentinel lymph node with a single investigation. Carbon dye is a sensitive and persistent visual marker of MRI-targeted sentinel lymph nodes. (c) 2005 Wiley Periodicals, Inc.