Bowen's disease showing spontaneous complete regression associated with apoptosis
Bowen's disease showing spontaneous complete regression associated with apoptosis
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鲍文氏病显示与细胞凋亡相关的自发完全消退
DOI：
10.1046/j.1365-2133.1999.02831.x
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发表时间：
1999
影响因子：
10.3
通讯作者：
F. Yudate
中科院分区：
文献类型：
--
作者：
M. Chisiki;A. Kawada;M. Akiyama;Y. Itoh;S. Tajima;A. Ishibashi;F. Yudate
自发性消退有时见于恶性皮肤肿瘤。我们报告了一名68岁的女性，其Bowen病表现出自发性完全消退。在消退病变的真皮上层发现显著的T细胞浸润和血管增多。Fas（APO-1/CD 95）抗原（一种凋亡相关的肿瘤坏死因子受体家族蛋白）在原发性病变中的强表达和消退后的微弱表达表明Fas介导的凋亡参与了我们患者Bowen病的自发完全消退。
Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68‐year‐old woman whose Bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Fas (APO‐1/CD95) antigen, an apoptosis‐related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas‐mediated apoptosis in the spontaneous complete regression of our patient's Bowen's disease.
影响因子：
11.2
作者：
J. Reynolds;Tao Yang;Liping Qian;J. Jenkinson;Ping Zhou;Alan Eastman;Roger Craig
通讯作者：
J. Reynolds;Tao Yang;Liping Qian;J. Jenkinson;Ping Zhou;Alan Eastman;Roger Craig