Omega 3 Fatty Acid and Skin Diseases.

Omega 3 Fatty Acid and Skin Diseases.
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DOI:
10.3389/fimmu.2020.623052
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发表时间:
2020
影响因子:
7.3
通讯作者:
Nakamura M
Nakamura M
中科院分区:
医学2区
文献类型:
--
作者:
Sawada Y;Saito-Sasaki N;Nakamura M

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人类暴露在各种外部环境因素中。食物摄入量是影响日常生活方式的最重要因素之一。在从食物中获取的营养素中,omega-3多不饱和脂肪酸(PUFAs)对炎症性疾病有各种有益的作用。此外,已知omega-3多不饱和脂肪酸代谢物,包括解析素,在过敏和炎症性疾病中显示出强大的抗炎作用;然而,关于这些代谢物对皮肤病的实际影响,人们知之甚少。在这篇综述中,除了omega-3多不饱和脂肪酸代谢产物对各种细胞的实际作用外,我们还重点介绍了在各种炎症性疾病中具有强烈抗炎作用的代谢物,以及那些在恶性肿瘤中具有抗肿瘤作用的代谢物。
Humans are exposed to various external environmental factors. Food intake is one of the most influential factors impacting daily lifestyle. Among nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have various beneficial effects on inflammatory diseases. Furthermore, omega-3 PUFA metabolites, including resolvins, are known to demonstrate strong anti-inflammatory effects during allergic and inflammatory diseases; however, little is known regarding the actual impact of these metabolites on skin diseases. In this review, we focused on metabolites that have strong anti-inflammatory actions in various inflammatory diseases, as well as those that present antitumor actions in malignancies, in addition to the actual effect of omega-3 PUFA metabolites on various cells.
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