Encapsulation of Inorganic Nanomaterials inside Virus-Based Nanoparticles for Bioimaging.
Encapsulation of Inorganic Nanomaterials inside Virus-Based Nanoparticles for Bioimaging.
复制标题
将无机纳米材料封装在基于病毒的纳米颗粒内用于生物成像
作者：
Zhang W;Xu C;Yin GQ;Zhang XE;Wang Q;Li F
基于病毒的纳米颗粒（VNPs）可以作为无机纳米材料的容器，具有优异的物理和化学性能。将纳米材料并入VNPs的内腔中为生物学和医学领域的成像应用开辟了许多可能性。将无机纳米粒子封装在VNPs中，可以实现纳米探针对VNPs的标记，同时保持VNPs原有的外表面特征。反过来，VNP增强了无机货物的稳定性和生物相容性。本文简要介绍了无机纳米材料在VNPs中的矿化和自组装技术，以及这些杂化纳米结构在生物成像领域的应用，包括体外和体内荧光成像、磁共振成像和诊断治疗。最后讨论了基于VNP平台的纳米光子学研究。我们预计，这一领域将继续蓬勃发展，与新的令人兴奋的机会，从VNPs的合理设计的进步，优秀的无机纳米材料的开发，多功能的集成，以及纳米生物界面相互作用的调节。
Virus-based nanoparticles (VNPs) can serve as containers for inorganic nanomaterials with excellent physical and chemical properties. Incorporation of nanomaterials inside the inner cavity of VNPs has opened up lots of possibilities for imaging applications in the field of biology and medicine. Encapsulation of inorganic nanoparticles (NPs) in VNPs can achieve the labeling of VNPs with nanoprobes and maintain the original outer surface features of VNPs at the same time. In return, VNPs enhance the stability and biocompatibility of the inorganic cargoes. This review briefly summarizes the current typical strategies to encapsulate inorganic nanomaterials in VNPs, i.e. mineralization and self-assembly, as well as the applications of these hybrid nanostructures in the field of bioimaging, including in vitro and in vivo fluorescence imaging, magnetic resonance imaging, and theranostics. Nanophotonic studies based on the VNP platform are also discussed. We anticipate that this field will continue to flourish, with new exciting opportunities stemming from advancements in the rational design of VNPs, the development of excellent inorganic nanomaterials, the integration of multiple functionalities, and the regulation of nano-bio interfacial interactions.