IFN-zeta/ limitin: a member of type I IFN with mild lympho-myelosuppression.
IFN-zeta/ limitin: a member of type I IFN with mild lympho-myelosuppression.
复制标题
DOI：
--
复制
发表时间：
2005
影响因子：
5.3
通讯作者：
K. Oritani;Y. Kanakura
中科院分区：
文献类型：
--
作者：
K. Oritani;Y. Kanakura
干扰素(IFN)-Zeta/limit被国际干扰素和细胞因子研究学会命名委员会认为是一种新型I型干扰素。IFN-Zeta/限制蛋白与ifn - α和ifn - β具有一定的序列同源性，具有5个α螺旋和4个环的球状结构，识别ifn - α / β受体。虽然IFN-zeta/限制蛋白具有抗病毒、免疫调节和抗肿瘤作用，但其淋巴骨髓抑制活性远低于ifn - α。用I型ifn处理细胞诱导和/或激活一些调节细胞周期和凋亡的分子。值得注意的是，IFN-zeta/limit激活Tyk2-Daxx和Tyk2-Crk通路的能力弱于IFN-alpha。由于使用反义寡核苷酸的实验已经揭示了它们在I型ifn相关的淋巴造血抑制中的重要作用，IFN-zeta/限制蛋白激活tyk2依赖性信号通路的能力很小，这可能解释了其独特的窄范围生物活性。进一步分析I型ifn的结构-功能关系，将建立具有IFN-zeta/limit有用特征的工程细胞因子。
Interferon (IFN)-Zeta/limitin has been considered as a novel type I IFN by the Nomenclature Committee of the International Society for Interferon and Cytokine Research. IFN-Zeta/limitin shows some sequence homology with IFN-alpha and IFN-beta, has a globular structure with five alpha-helices and four loops, and recognizes IFN-alpha/beta receptor. Although IFN-zeta/limitin displays antiviral, immunomodulatory, and antitumor effects, it has much less lympho-myelosuppressive activities than IFN-alpha. Treatment of cells with type I IFNs induces and/or activates a number of molecules, which regulate cell cycle and apoptosis. It is noteworthy that IFN-zeta/limitin activates the Tyk2-Daxx and Tyk2-Crk pathways weaker than IFN-alpha. Because experiments using antisense oligonucleotides have revealed their essential role in type I IFN-related suppression of lympho-hematopoiesis, little ability of IFN-zeta/limitin to activate the Tyk2-dependent signaling pathway may explain its uniquely narrow range of biological activities. Further analysis of structure-function relationship of type I IFNs will establish an engineered cytokine with useful features of IFN-zeta/limitin.