Catalytic alkyne hydrothiolation with alkanethiols using Wilkinson's catalyst
Catalytic alkyne hydrothiolation with alkanethiols using Wilkinson's catalyst
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DOI：
10.1021/om700811e
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发表时间：
2007-11-19
期刊：
影响因子：
2.8
通讯作者：
Love, Jennifer A.
中科院分区：
文献类型：
--
作者：
Shoai, Shiva;Bichler, Paul;Love, Jennifer A.
我们最近发现，威尔金森的催化剂（ClRh（PPh 3）（3））是用于炔与烷硫醇氢硫醇化以提供线性烷基（E）-乙烯基硫醚的优异催化剂，所述线性烷基（E）-乙烯基硫醚是有价值的合成中间体和生物活性分子的前体。氘标记的研究表明，反应进行硫醇氧化加成，炔迁移插入，和随后的还原消除。
We recently discovered that Wilkinson's catalyst (ClRh(PPh3)(3)) is an excellent catalyst for alkyne hydrothiolation with alkanethiols to provide linear alkyl (E)-vinyl sulflides, which are valuable synthetic intermediates and precursors to bioactive molecules. Deuterium-labeling studies indicate that the reaction proceeds by thiol oxidative addition, alkyne migratory insertion, and subsequent reductive elimination.