Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin
Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin
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DOI：
10.1023/a:1020211714104
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发表时间：
2002-08-01
影响因子：
4.4
通讯作者：
Schauer, R
中科院分区：
文献类型：
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作者：
Kohla, G;Stockfleth, E;Schauer, R
神经节苷脂在其碳水化合物部分中携带O-乙酰化唾液酸，通常存在于生长和发育组织中，特别是神经外胚层来源的组织中。最突出的一种是9-O-Ac-GD 3，其被认为是动物和人类肿瘤如神经元肿瘤、黑素瘤、基底细胞瘤或乳腺癌以及银屑病病变中的癌胚标志物。其他神经节苷脂如GD 2或GT 3也被发现在其末端唾液酸中被O-乙酰化。在这篇综述中，我们总结了这种神经节苷脂在正常和转化组织中的发生，并描绘了一个更一般的理论，即神经节苷脂中的O-乙酰化唾液酸是生长细胞和组织的通用标志物。
Gangliosides, carrying an O-acetylated sialic acid in their carbohydrate moiety, are often found in growing and developing tissues, especially of neuro-ectodermal origin. The most prominent one is 9-O-Ac-GD3, which is considered as an oncofetal marker in animal and human tumors like neuronal tumors, melanoma, basalioma or breast cancer, as well as in psoriatic lesions. Also other gangliosides like GD2 or GT3 were found to be O-acetylated in their terminal sialic acid. In this review we are summarising the occurrence of such gangliosides in normal and transformed tissues and delineate a more general theory that O-acetylated sialic acids in gangliosides are a universal marker for growing cells and tissues.