Neurobiological mechanisms by which nicotine mediates different types of anxiety
Neurobiological mechanisms by which nicotine mediates different types of anxiety
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DOI：
10.1016/s0014-2999(99)00889-4
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发表时间：
2000-03-30
影响因子：
5
通讯作者：
Kenny, PJ
中科院分区：
文献类型：
--
作者：
File, SE;Cheeta, S;Kenny, PJ
尼古丁对背侧海马和外侧隔的作用进一步证明了不同的神经化学和神经解剖学底物在不同的动物试验中控制行为。因此，在社交互动测试（广泛性焦虑障碍的模型）中，在产生中度焦虑的测试条件下，双侧给予尼古丁（1-4 μ g）至两个区域具有致焦虑作用。焦虑作用由尼古丁诱发的5-羟色胺（5-HT）释放增加介导，并由5-HT 1A受体拮抗剂N-（2-（6-（2-甲氧基苯基）-1-哌嗪基）乙基）-N-（2-吡啶基）环己烷甲酰胺（WAY 100，635）联合给药逆转。在高架十字迷宫（模拟惊恐障碍的逃避成分）中进行的试验1中，尼古丁在背侧海马给药时没有作用，但在侧隔给药后具有致焦虑作用。在高架十字迷宫（一种特定恐惧症模型）的试验2中，尼古丁（1 μ g）在背侧海马给药时具有抗焦虑作用，但在侧隔无效（4和8 μ g）。(C)2000 Elsevier Science B. V.保留所有权利。
The effects of nicotine administration into the dorsal hippocampus and lateral septum provide further evidence that different neurochemical and neuroanatomical substrates control behaviour in different animal tests. Thus, in the social interaction test (a model of generalised anxiety disorder), bilateral administration of nicotine (1-4 mu g) into both regions has anxiogenic effects in test conditions that generate moderate anxiety. The anxiogenic effects are mediated by a nicotine-evoked increase in 5-hydroxytryptamine (5-HT) release and an reversed by co-administration of the 5-HT1A receptor antagonist, N-(2-(6-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl)cyclohexane carboxamide trichloride (WAY 100,635). On trial 1 in the elevated plus-maze (which models the escape components of panic disorder), nicotine is without effect when administered to the dorsal hippocampus, but has anxiogenic effects after lateral septal administration. On trial 2 in the elevated plus-maze (a model of specific phobia), nicotine(1 mu g) has anxiolytic effects when administered to the dorsal hippocampus, but is ineffective (4 and 8 mu g) in the lateral septum. (C) 2000 Elsevier Science B.V. All rights reserved.