Design of Asynchronous Genetic Circuits
Design of Asynchronous Genetic Circuits
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DOI：
10.1109/jproc.2019.2916057
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发表时间：
2019-06
影响因子：
20.6
通讯作者：
Tramy Nguyen;Timothy S. Jones;P. Fontanarrosa;Jeanet V. Mante;Z. Zundel;D. Densmore;C. Myers
中科院分区：
文献类型：
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作者：
Tramy Nguyen;Timothy S. Jones;P. Fontanarrosa;Jeanet V. Mante;Z. Zundel;D. Densmore;C. Myers
大多数数字电子电路利用定时参考来同步信号的进展并启用顺序存储器元件。由于缺乏可靠的高频时钟信号，这些设计可能无法在生物基质中实现。异步设计消除了对具有数据编码和请求/确认握手协议的时钟的需要。本文提出了一种异步遗传电路自动化设计的工作流程。该工作流程通过利用针对该技术定制的异步逻辑设计方法来扩展遗传设计工具。该工作流程在遗传传感器上进行了演示，该传感器使用过滤和蜂窝通信来提高其可靠性。
Most digital electronic circuits utilize a timing reference to synchronize the progression of signals and enable sequential memory elements. These designs may not be realizable in biological substrates due to the lack of a reliable high-frequency clock signal. Asynchronous designs eliminate the need for a clock with data encodings and request/acknowledge handshake protocols. This paper proposes a workflow to automate the design of asynchronous genetic circuits. This workflow extends genetic design tools by leveraging asynchronous logic design methods customized for this technology. This workflow is demonstrated on a genetic sensor that uses filtering and cellular communication to improve its reliability.