Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
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DOI：
10.1016/j.ijdevneu.2004.05.005
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发表时间：
2005-04-01
影响因子：
1.8
通讯作者：
Patterson, PH
中科院分区：
文献类型：
--
作者：
Shi, LM;Tu, N;Patterson, PH
流行病学研究表明，母体感染会增加后代患精神疾病的风险。在母体呼吸道感染流感病毒的小鼠模型中，成年后代表现出显著的行为、药理和组织学异常。虽然流感主要感染呼吸系统，但有报道称，在受感染的怀孕动物的胎儿中存在病毒mRNA和蛋白质。为了确定母体呼吸道感染后病毒传播的程度，我们使用RT-PCR检测了不同母体和胎儿组织中编码神经氨酸酶、非结构蛋白2、核蛋白和基质蛋白的甲型流感mRNAs。虽然受感染的母亲肺显示出一致非常强的信号，但胎盘很少呈阳性，在受感染母亲的胎儿大脑中检测不到病毒RNA。因此，母体感染对胎儿大脑发育的影响可能是间接的，可能涉及母体的炎症反应。(C)2004年综合业务数字网。爱思唯尔有限公司出版。保留所有权利。
Epidemiological studies have shown that maternal infection can increase the risk for mental illness in the offspring. In a mouse model of maternal respiratory infection with influenza virus, the adult offspring display striking behavioral, pharmacological and histological abnormalities. Although influenza primarily infects the respiratory system, there are reports of viral mRNA and protein in the fetus of infected pregnant animals. To determine the extent of viral spread following maternal respiratory infection, we used RT-PCR to assay various maternal and fetal tissues for influenza A mRNAs coding for neuraminidase, non-structural protein 2, nuclear protein and matrix protein. While infected maternal lungs exhibit uniformly very strong signals, placentae are only rarely positive, and viral RNAs are not detectable in fetal brains from infected mothers. Thus, the effects of maternal infection on fetal brain development are likely to be indirect, probably involving the maternal inflammatory response. (C) 2004 ISDN. Published by Elsevier Ltd. All rights reserved.