Long‐lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP‐ribose) polymerase
Long‐lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP‐ribose) polymerase
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DOI：
10.1111/j.1476-5381.2011.01666.x
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发表时间：
2012-03
影响因子：
7.3
通讯作者：
F. Moroni;A. Cozzi;A. Chiarugi;L. Formentini;E. Camaioni;D. Pellegrini-Giampietro;Yi Chen;S. Liang-S.
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文献类型：
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作者：
F. Moroni;A. Cozzi;A. Chiarugi;L. Formentini;E. Camaioni;D. Pellegrini-Giampietro;Yi Chen;S. Liang-S.
噻吩基异喹诺酮（TIQ-A）是一种相对有效的PARP抑制剂，能够在体外减少缺血后神经元死亡。在这里，我们在不同的中风模型中研究了DAMTIQ和HYDAMTIQ的神经保护特性，这两种TIQ-A衍生物能够到达大脑并抑制PARP-1和PARP-2。
BACKGROUND AND PURPOSES Thienyl‐isoquinolone (TIQ‐A) is a relatively potent PARP inhibitor able to reduce post‐ischaemic neuronal death in vitro. Here we have studied, in different stroke models in vivo, the neuroprotective properties of DAMTIQ and HYDAMTIQ, two TIQ‐A derivatives able to reach the brain and to inhibit PARP‐1 and PARP‐2.