Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity
Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity
复制标题
基于G-四链体构象相关DNAzyme活性的血清钠离子比色检测
DOI：
10.1016/j.aca.2016.01.041
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发表时间：
2016-03-17
影响因子：
6.2
通讯作者：
Tang, Yalin
中科院分区：
文献类型：
--
作者：
Sun, Hongxia;Chen, Hongbo;Tang, Yalin
因此，在生理系统中，由于大量的K+的干扰，开发实用的Na+传感器具有很大的挑战性。本研究基于G-四链体构象与DNA酶活性的关系，设计了一种新型的Na+传感器。该传感器具有很高的选择性和灵敏度，检测限为0.6 μ M，这使得该传感器能够实际用于测定血清中的Na+水平。该研究不仅提供了一种简单的Na+传感器，而且为Na+检测技术的发展开辟了一条新的途径。(C)2016爱思唯尔B. V.保留所有权利。
There has been a big challenge in developing the Na+ sensor that can be practically used in the physiological system with the interference of large amounts of K+. In this research, a novel Na+ sensor has been designed based on the G-quadruplex-conformation related DNAzyme activity. The sensor exhibits high selectivity and sensitivity with the detection limit of 0.6 mu M, which enables the sensor to be practically used in determination of the Na+ level in serum. The research not only provides a simple Na+ sensor but also opens a new way for developing the detection technology of Na+. (C) 2016 Elsevier B.V. All rights reserved.