Effect of cobalt on the liver glycogen content in the streptozotocin-induced diabetic rats
Effect of cobalt on the liver glycogen content in the streptozotocin-induced diabetic rats
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DOI：
10.1007/s11010-005-5777-y
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发表时间：
2005-09-01
影响因子：
4.3
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Nomura, Y;Okamoto, S;Nakamura, T
钴可降低糖尿病大鼠的血糖，但其机制尚不清楚。为探讨糖原代谢在降糖作用中的作用，测定了链脲佐菌素诱导的糖尿病大鼠肝脏和肌肉中糖原含量。糖尿病大鼠肝糖原耗竭。但当给大鼠注射钴时，糖原恢复到健康大鼠的水平，同时血糖下降。钴治疗对糖尿病大鼠的肌糖原无影响。糖原代谢的组织特异性反应表明，钴治疗导致的高血糖素信号被抑制。
Cobalt decreases blood glucose in diabetic rats but the mechanisms involved are unclear. To determine the contribution of glycogen metabolism to glycemia-lowering effect, glycogen contents of liver and muscle in the streptozotocin-induced diabetic rats were determined. The liver glycogen was depleted in diabetic rats. But when cobalt was administered to the rats, the glycogen returned to the level of healthy rats, concomitantly with the decrease in blood glucose. The cobalt treatment had no effect on the muscle glycogen in the diabetic rats. The tissue-specific responses of glycogen metabolism suggest the involvement of suppressed glucagon signaling due to cobalt treatment.