Which seizure-precipitating factors do patients with epilepsy most frequently report?
Which seizure-precipitating factors do patients with epilepsy most frequently report?
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DOI：
10.1016/j.yebeh.2004.11.003
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发表时间：
2005-02-01
影响因子：
2.6
通讯作者：
Corey, LA
中科院分区：
文献类型：
--
作者：
Nakken, KO;Solaas, MH;Corey, LA
在治疗癫痫患者时，处理诱发癫痫的因素在一定程度上被忽视和低估，是对更传统疗法的补充。本研究的目的是调查大量癫痫人群中癫痫发作前兆的发生率，并确定哪些前兆患者最常报告。研究参与者包括从挪威双胞胎小组（NTP）、丹麦双胞胎登记处（DTR）和中大西洋双胞胎登记处（MATR）确定的双胞胎及其家庭成员。一千六千七十七名癫痫患者被确定，并使用封闭式问卷询问癫痫发作的促发因素。53%的人报告至少有一种诱发癫痫的因素，而30%的人声称经历过两种或两种以上的因素。情绪压力、睡眠不足和疲劳是三个最常见的诱因。全身性癫痫发作的患者似乎比部分性癫痫发作的患者对睡眠剥夺和闪烁的光线更敏感，而部分性癫痫发作的女性似乎比全身性癫痫发作的女性更容易在月经期间发作。了解癫痫发作促发物不仅在患者治疗和咨询方面有实际意义，而且在诊断方面也有实际意义，因为它可能有助于促进脑电图和脑电图记录中癫痫样放电的出现。(C) 2004爱思唯尔公司版权所有。
When treating patients with epilepsy, dealing with seizure-precipitating factors is a partly neglected and underestimated supplement to more traditional therapies. The aim of this study was to investigate the incidence of seizure precipitants in a large epilepsy population and to determine which precipitants patients most often reported. Study participants included twins and their family members ascertained from the Norwegian Twin Panel (NTP), the Danish Twin Registry (DTR), and the Mid-Atlantic Twin Registry (MATR). One thousand six hundred seventy-seven patients with epilepsy were identified and were asked about seizure precipitants using a closed-ended questionnaire. Fifty-three percent reported at least one seizure-precipitating factor, while 30% claimed to have experienced two or more such factors. Emotional stress, sleep deprivation, and tiredness were the three most frequently reported precipitants. Patients with generalized seizures seemed to be more sensitive to sleep deprivation and flickering light than those with partial seizures, while women with partial seizures appeared to be more prone to seizures during menstruation than women with generalized seizures. Knowledge of seizure precipitants has practical implications, not only in patient treatment and counseling, but also for diagnosis, in that it may be helpful in facilitating the appearance of interictal epileptiform discharges in EEG and ictal EEG recordings. (C) 2004 Elsevier Inc. All rights reserved.