Population genetics of the coral Acropora millepora: Toward genomic prediction of bleaching
Population genetics of the coral Acropora millepora: Toward genomic prediction of bleaching
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DOI：
10.1126/science.aba4674
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发表时间：
2020-07-17
期刊：
影响因子：
56.9
通讯作者：
Przeworski, Molly
中科院分区：
文献类型：
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作者：
Fuller, Zachary L.;Mocellin, Veronique J. L.;Przeworski, Molly
虽然造礁珊瑚在世界范围内正在减少，但对漂白的反应在物种内部和物种之间各不相同，部分是遗传的。为了从基因组数据预测漂白反应，我们为珊瑚鹿角珊瑚产生了一个染色体规模的基因组组装。我们获得了237个表型样本的全基因组序列，收集在12个珊瑚礁沿着大堡礁，其中我们推断很少的人口结构。通过扫描基因组寻找局部适应的证据，我们在热休克辅助分子伴侣囊蛋白中发现了长期平衡选择的特征。我们对213个样本的视觉漂白评分进行了全基因组关联研究，将其衍生的多基因评分纳入野生漂白的预测模型。这些结果为基于基因组学的保护策略奠定了基础。
Although reef-building corals are declining worldwide, responses to bleaching vary within and across species and are partly heritable. Toward predicting bleaching response from genomic data, we generated a chromosome-scale genome assembly for the coral Acropora millepora. We obtained whole-genome sequences for 237 phenotyped samples collected at 12 reefs along the Great Barrier Reef, among which we inferred little population structure. Scanning the genome for evidence of local adaptation, we detected signatures of long-term balancing selection in the heat-shock co-chaperone sacsin. We conducted a genome-wide association study of visual bleaching score for 213 samples, incorporating the polygenic score derived from it into a predictive model for bleaching in the wild. These results set the stage for genomics-based approaches in conservation strategies.