ENKEPHALIN, DYNORPHIN AND SUBSTANCE-P IN POSTMORTEM SUBSTANTIA-NIGRA FROM NORMALS AND SCHIZOPHRENIC-PATIENTS
ENKEPHALIN, DYNORPHIN AND SUBSTANCE-P IN POSTMORTEM SUBSTANTIA-NIGRA FROM NORMALS AND SCHIZOPHRENIC-PATIENTS
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DOI：
10.1016/0024-3205(91)90224-y
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发表时间：
1991-01-01
期刊：
影响因子：
6.1
通讯作者：
KLEINMAN, JE
中科院分区：
文献类型：
--
作者：
IADAROLA, MJ;OFRI, D;KLEINMAN, JE
三种肽类神经调质，发现在黑质中的高浓度：强啡肽A1 -8，甲硫氨酸5-脑啡肽-精氨酸6-甘氨酸7-亮氨酸8和P物质，测定了特定的放射免疫分析在黑质组织从正常人和精神分裂症死后。 P物质和强啡肽在两组之间没有变化。 然而，前脑啡肽衍生肽显着升高精神分裂症组。 经高压液相色谱法鉴定，其免疫反应性为真正的甲硫氨酸5-脑啡肽-精氨酸6-甘氨酸7-亮氨酸8（met 5-enkephalin-arg 6-gly 7-leu 8）。 这些数据表明，黑质脑啡肽肽相比强啡肽和P物质，存在一套不同的监管控制，前一个系统可能会在精神分裂症紊乱。
Three peptide neuromodulators that are found in high concentration in the subtantia nigra: dynorphin A 1-8, met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.