Reduction of noradrenaline impairs attention and dopamine depletion slows responses in Parkinson's disease
Reduction of noradrenaline impairs attention and dopamine depletion slows responses in Parkinson's disease
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DOI：
10.1046/j.1460-9568.1998.00145.x
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发表时间：
1998-04-01
影响因子：
3.4
通讯作者：
Riekkinen, P
中科院分区：
文献类型：
--
作者：
Riekkinen, M;Kejonen, K;Riekkinen, P
我们研究了多巴胺和去甲肾上腺素在帕金森病 (PD) 患者注意力调节中的作用。我们观察到，轻度和中度运动障碍的 PD 患者在简单测试中的注意力准确性没有差异，但重度 PD 组在更困难的注意力测试中略有干扰。轻度或重度帕金森病患者的注意力准确性不受多巴胺能药物停药的影响。重度PD患者运动较慢，多巴胺能药物停药使重度PD患者运动减慢更加严重。可乐定（0.5 和 2 μg/kg）会降低轻度 PD 患者在最困难的注意力测试中表现的准确性，但对重度 PD 组没有影响。可乐定对运动时间没有影响。这些数据表明，去甲肾上腺素释放缺陷可能会导致严重帕金森病患者注意力的准确性受损，而多巴胺可能对维持快速运动反应很重要。
We investigated the role dopamine and noradrenaline in the modulation of attention in Parkinson's disease (PD) patients. We observed that PD patients with mild and moderate motor disability did not differ in their attentional accuracy in easy tests, but the severe PD group was slightly disrupted in a more arduous test of attention. Attentional accuracy was not affected by withdrawal of dopaminergic drugs in mild or severe PD patients. The movements of severe PD patients were slower, and withdrawal of dopaminergic drugs aggravated motor slowing more in severe PD patients. Clonidine (0.5 and 2 mu g/kg) retarded accuracy of performance in the most difficult attention test in mild PD patients, but had no effect in the severe PD group. Clonidine had no effect on movement times. These data suggest that a defect in noradrenaline release may contribute to the impaired accuracy of attention in severe PD patients and that dopamine may be important for maintaining rapid motor responding.