DAPTOMYCIN DISRUPTS MEMBRANE-POTENTIAL IN GROWING STAPHYLOCOCCUS-AUREUS
DAPTOMYCIN DISRUPTS MEMBRANE-POTENTIAL IN GROWING STAPHYLOCOCCUS-AUREUS
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DOI：
10.1128/aac.35.11.2282
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发表时间：
1991-11-01
影响因子：
4.9
通讯作者：
PRESTON, DA
中科院分区：
文献类型：
--
作者：
ALBORN, WE;ALLEN, NE;PRESTON, DA
达托霉素（LY 146032）引起金黄色葡萄球菌膜电位（Δ-PSI）的钙依赖性耗散，而不明显影响跨膜的化学梯度（Δ-pH）。 达托霉素对膜通透性的影响可能是该抗生素对大分子生物合成和膜功能的许多抑制作用的原因。 我们的证据表明，达托霉素的杀菌活性取决于可用的DELTA-PSI。
Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (DELTA-PSI) in Staphylococcus aureus without noticeably affecting the chemical gradient (DELTA-pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available DELTA-PSI.