Apoptosis and T-cell depletion during feline infectious peritonitis
Apoptosis and T-cell depletion during feline infectious peritonitis
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DOI：
10.1128/jvi.70.12.8977-8983.1996
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发表时间：
1996-12-01
影响因子：
5.4
通讯作者：
Horzinek, MC
中科院分区：
文献类型：
--
作者：
Haagmans, BL;Egberink, HF;Horzinek, MC
屈服于猫感染性腹膜炎的猫是由猫科罗尼亚病毒的变异引起的免疫介导的疾病，其淋巴机器人的细胞凋亡和T细胞耗竭。在这种情况下发展的腹水会在体外导致凋亡，但仅在活化的T细胞中。由于猫感染性腹膜炎病毒不感染T细胞，并且病毒蛋白不抑制T细胞增殖，因此我们假设在感染期间释放的可溶性介质会导致细胞凋亡和T细胞耗竭。
Cats that have succumbed to feline infectious peritonitis, an immune-mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs. The ascitic fluid that develops in the course of the condition causes apoptosis in vitro but only in activated T cells. Since feline infectious peritonitis virus does not infect T cells, and viral proteins did not inhibit T-cell proliferation, we postulate that soluble mediators released during the infection cause apoptosis and T-cell depletion.