Empirically derived patterns of psychiatric symptoms in youth: A latent profile analysis.
Empirically derived patterns of psychiatric symptoms in youth: A latent profile analysis.
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DOI：
10.1016/j.jad.2016.09.016
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发表时间：
2017-07
影响因子：
6.6
通讯作者：
Brotman MA
中科院分区：
文献类型：
--
作者：
Kircanski K;Zhang S;Stringaris A;Wiggins JL;Towbin KE;Pine DS;Leibenluft E;Brotman MA
通过概念化的行为领域transdiagnosically，国家精神卫生研究所研究领域标准（NIMH RDoC）的倡议促进了研究精神病症状的新方法。在这项研究中，潜在的配置文件分析（LPA）被用来经验性地得出类或模式的精神症状在青年横断传统的疾病分类的界限。数据来自509名儿童和青少年（年龄7至18岁;平均年龄= 12.9岁; 54%为男性），他们在NIMH情感和发展分支进行了评估，并且在诊断和症状方面具有异质性。青少年和/或他们的父母完成了几个核心症状维度的测量：易怒、焦虑、抑郁和注意力缺陷多动障碍（ADHD）。LPA被用来解析响应模式到不同的类，根据不同的措施，分数的水平和相互关系。出现了五个阶级：低水平的焦虑（52%的样本）;焦虑和轻度抑郁症状（17%）;父母报告的易怒和ADHD（16%）;易怒和混合共病症状（10%）;以及高水平的易怒，焦虑，抑郁和ADHD（5%）。重要的是，这些潜在类别跨越了被调查者和最初评估青年的临床条件。此外，以易怒为特征的班级表现出最差的整体功能。这些数据是横截面的。检查外部验证，包括神经生物学相关和症状过程，是必要的。结果告知我们的理解，青年精神症状的结构，并提出新的方法来操作精神病理学和检查它与神经生物学。
By conceptualizing domains of behavior transdiagnostically, the National Institute of Mental Health Research Domain Criteria (NIMH RDoC) initiative facilitates new ways of studying psychiatric symptoms. In this study, latent profile analysis (LPA) was used to empirically derive classes or patterns of psychiatric symptoms in youth that transect traditional nosologic boundaries. Data were drawn from 509 children and adolescents (ages 7 to 18 years; mean age = 12.9 years; 54% male) who were evaluated in the NIMH Emotion and Development Branch and were heterogeneous with respect to presenting diagnoses and symptoms. Youth and/or their parents completed measures of several core symptom dimensions: irritability, anxiety, depression, and attention deficit hyperactivity disorder (ADHD). LPA was used to parse response patterns into distinct classes, based on the levels of, and interrelations among, scores on the different measures. Five classes emerged: low levels of symptomatology (52% of sample); anxiety and mild depressive symptoms (17%); parent-reported irritability and ADHD (16%); irritability and mixed comorbid symptoms (10%); and high levels of irritability, anxiety, depression, and ADHD (5%). Importantly, these latent classes cut across informants and the clinical conditions for which youth were initially evaluated. Further, the classes characterized by irritability exhibited the poorest overall functioning. These data were cross-sectional. Examination of external validators, including neurobiological correlates and symptom course, is warranted. Results inform our understanding of the structure of psychiatric symptoms in youth and suggest new ways to operationalize psychopathology and examine it in relation to neurobiology.