HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease
HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease
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中国汉族晚发散发性帕金森病患者HLA rs3129882变异
DOI：
10.1016/j.neulet.2011.05.245
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发表时间：
2011-09-01
影响因子：
2.5
通讯作者：
Deng, Hao
中科院分区：
文献类型：
--
作者：
Guo, Yi;Deng, Xiong;Deng, Hao
最近，在欧洲血统的美国人中，发现HLA-HLA内含子1中的rs3129882变异与迟发性散发性帕金森病（PD）相关。为了评估是否相同的变异与中国人群中的PD，我们调查了中国大陆汉族人群中晚发散发性PD患者。我们发现患者和对照组之间的基因型和等位基因分布存在显著差异（基因型分布的chi（2）=6.446，p=0.040;等位基因分布的chi（2）=5.762，p=0.016），表明该变异与中国汉族人群中迟发性散发性PD相关。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (chi(2)=6.446, p=0.040 for genotypic distribution; chi(2)=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.