Association of vitamin D deficiency with cognitive impairment in older women Cross-sectional study
Association of vitamin D deficiency with cognitive impairment in older women Cross-sectional study
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DOI：
10.1212/wnl.0b013e3181beecd3
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发表时间：
2010-01-05
期刊：
影响因子：
9.9
通讯作者：
Beauchet, O.
中科院分区：
文献类型：
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作者：
Annweiler, C.;Schott, A. M.;Beauchet, O.
目的：仅有少数研究调查了低血清 25-羟基维生素 D [25(OH) D] 浓度与认知能力下降之间的关联，但结果不一。这项基于人群的横断面研究的目的是在考虑混杂因素的同时，探讨血清 25(OH) D 缺乏与认知障碍之间的关联。 方法：受试者为来自骨质疏松流行病学 (EPIDOS) 队列的 752 名年龄 >= 75 岁的女性，根据血清 25(OH) D 浓度（要么缺乏，= 10 ng/mL）分为 2 组。认知障碍被定义为 Pfeiffer 简短便携式精神状态问卷 (SPMSQ) 评分 = 10 ng/mL (n = 623)，患有 25(OH) D 缺乏症的女性 (n = 129) 平均 SPMSQ 评分较低 (p < 0.001)，且 SPMSQ 评分更常见
Objective: The association between low serum 25-hydroxyvitamin D [25(OH) D] concentration and cognitive decline has been investigated by only a few studies, with mixed results. The objective of this cross-sectional population-based study was to examine the association between serum 25(OH) D deficiency and cognitive impairment while taking confounders into account.Methods: The subjects, 752 women aged >= 75 years from the Epidemiologie de l'Osteoporose (EPIDOS) cohort, were divided into 2 groups according to serum 25(OH) D concentrations (either deficient, = 10 ng/mL). Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score = 10 ng/mL (n = 623), the women with 25(OH) D deficiency (n = 129) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score