Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse.
Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse.
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小鼠的去唾液酸糖蛋白受体基因连接在 11 号染色体上。
DOI：
10.1089/dna.1988.7.721
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Doyle,D
中科院分区：
文献类型：
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作者：
Sanford,JP;Elliott,RW;Doyle,D
肝细胞质膜上的asialal糖蛋白受体识别半乳糖终止的糖蛋白，并将其内化，以便随后在溶酶体中降解。大鼠受体，也被称为大鼠肝凝集素（RHL），由三个蛋白质亚基组成，分别是RHL-1、RHL-2和RHL-3；两个基因分别编码RHL-1和RHL-2/3。我们克隆了RHL-2/3基因并对其进行了测序，发现在小鼠基因组中存在同源的asialal糖蛋白受体基因。生物化学研究表明，受体亚基在发育过程中表现出相同的时间表达，并以协调的方式发挥作用。这项研究询问小鼠受体基因是否相互关联，从而可能对共享作用调控元件作出反应。利用限制性片段长度多态性（RFLPs）和重组自交系，我们将两个紧密相连的小鼠肝凝集素（MHL）基因定位到11号染色体上。Asgris指定命名亚洲糖蛋白基因位点。讨论了该连锁基因家族的协调调控。
The asialoglycoprotein receptor on the hepatocyte plasma membrane recognizes galactose-terminated glycoproteins and internalizes them for subsequent degradation in lysosomes. The rat receptor, also known as rat hepatic lectin (RHL), is comprised of three protein subunits called RHL-1, RHL-2, and RHL-3; two genes code for RHL-1 and RHL-2/3, respectively. We have cloned and sequenced the gene for RHL-2/3, and demonstrated that homologous asialoglycoprotein receptor genes exist in the mouse genome. Biochemical studies have demonstrated that receptor subunits exhibit the same temporal expression during development and function in a coordinate manner. This study asks if mouse receptor genes are linked and thus could possibly respond to sharedcis-acting regulatory elements. Using restriction fragment length polymorphisms (RFLPs) and recombinant inbred lines, we mapped two closely linked mouse hepatic lectin (MHL) genes to chromosome 11.Asgris designated to name asialoglycoprotein gene loci. Coordinate regulation of this linked gene family is discussed.