Semen infections in men with primary infertility in the real-life setting
Semen infections in men with primary infertility in the real-life setting
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DOI：
10.1016/j.fertnstert.2020.01.034
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发表时间：
2020-06-01
影响因子：
6.7
通讯作者：
Salonia, Andrea
中科院分区：
文献类型：
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作者：
Boeri, Luca;Pederzoli, Filippo;Salonia, Andrea
目的：研究无症状精液感染对原发夫妇不育男性精液参数的影响。设计：横断面研究。设置：学术中心。患者：分析了1689例不育男性的社会人口学、临床和实验室数据。干预：精液分析基于2010年世界卫生组织参考标准。每例患者均进行精液培养试验，以确定常见的泌尿生殖道病原体。支原体、脲原体和衣原体属感染。通过真实的时间聚合酶链反应平台进行评价。描述性统计和线性和逻辑回归模型被用来测试精液感染和临床，精液，和激素parameters.Main结果Measure（S）之间的关联：无症状的精液感染的患病率和精液感染对精子parameters.Results的影响：在1689名男子，354（21.0%）有一个无症状的阳性精液培养。解脲脲原体（37.6%）是最常见的单一病原体，其次是肠杆菌科（任何类型; 24.8%），其他病原体（20.3%），沙眼衣原体（3.4%）和支原体属（3.4%）。精液培养阳性与较低的精子浓度相关（P
Objective: To study the impact of asymptomatic semen infections on seminal parameters in men presenting for primary couple's infertility.Design: Cross-sectional study.Setting: Academic center.Patients: Socio-demographic, clinical, and laboratory data from 1689 infertile men were analyzed.Intervention(s): Semen analysis was based on 2010 World Health Organization reference criteria. Each patient underwent semen culture test to identify common urogenital pathogens. Infections by Mycoplasma, Ureaplasma, and Chlamydia spp. were evaluated through a real time polymerase chain reaction platform. Descriptive statistics and linear and logistic regression models were used to test the association between semen infections and clinical, seminal, and hormonal parameters.Main Outcome Measure(s): Prevalence of asymptomatic semen infection and impact of semen infection on sperm parameters.Results: Of 1689 men, 354 (21.0%) had an asymptomatic positive semen culture. Ureaplasma urealyticum (37.6%) was the most frequent single pathogen, followed by Enterobacteriaceae (any type; 24.8%), other pathogens (20.3%), Chlamydia trachomatis (3.4%) and Mycoplasma spp (3.4%). Positive semen cultures were associated with lower sperm concentrations (P