YEAST IN BLOOD CULTURES - EVALUATION OF FACTORS INFLUENCING OUTCOME
YEAST IN BLOOD CULTURES - EVALUATION OF FACTORS INFLUENCING OUTCOME
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DOI：
10.1016/0732-8893(92)90118-d
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发表时间：
1992-03-01
影响因子：
2.9
通讯作者：
COLDMAN, AJ
中科院分区：
文献类型：
--
作者：
BRYCE, EA;ROBERTS, FJ;COLDMAN, AJ
回顾性分析了1987年1月至1989年9月间发生的60例念珠菌血症，并比较了3类患者的结局：血小板减少性、手术后和非血小板减少性非手术。 由于耐药酵母菌的报告越来越多，确定了对阿替霉素B（amB）的最小抑菌浓度（MIC），以检查其与患者结局的关系。 在选定的危险因素、死亡率或分离的菌种方面，患者类别之间没有显著差异，尽管热带念珠菌有发生在血小板减少症患者中的趋势。 使用逻辑回归的统计分析显示，amB剂量> 500 mg和酵母菌MIC > 0.78 μ g/ml是患者结果的独立决定因素。
Sixty episodes of candidemia occuring between January 1987 and September 1989 were retrospectively reviewed and the outcome was compared for three patient categories: neutropenic, postsurgical, and nonneutropenic nonsurgical. Because of increasing reports of resistant yeasts, minimal inhibitory concentrations (MICs) to amphotericin B (amB) were determined to examine its relationship to patient outcome. No significant differences between patient categories were found for selected risk factors, mortality, or species isolated, although there was a tendency for Candida tropicalis to occur in neutropenic patients. Statistical analysis using logistic regression showed that both an amB dose > 500 mg and a yeast MIC > 0.78-mu-g/ml were independent prognosticators of patient outcome.