GENETIC INFLUENCE IN HEADACHES - A SWEDISH TWIN STUDY
GENETIC INFLUENCE IN HEADACHES - A SWEDISH TWIN STUDY
复制标题
DOI：
10.1111/j.1526-4610.1995.hed3509513.x
复制
发表时间：
1995-10-01
期刊：
影响因子：
5
通讯作者：
PEDERSEN, NL
中科院分区：
文献类型：
--
作者：
LARSSON, B;BILLE, B;PEDERSEN, NL
在瑞典双胞胎登记处的两个大型队列中检查了自我报告的偏头痛和非偏头痛性头痛的遗传性，该队列由6448对（老年队列）和12884对（年轻队列）相同性别的双胞胎组成。同卵双胞胎终生偏头痛的一致性率始终高于异卵双胞胎。还有偏头痛的复发致残型。此外，在可能是紧张型或轻度偏头痛（或两者兼而有之）的“混合”组中，同卵双胞胎的一致性率高于异卵双胞胎。结构方程模型拟合分析的结果显示，在两个队列中，遗传对偏头痛的影响在女性（估计范围为49%至58%）中强于男性（39%至44%）。独特的非共享环境对男女“混合”组的影响最大（估计从60%到69%不等）。结果讨论了类似的大规模双胞胎研究的遗传性倾向偏头痛。
The heritability of liability to self-reported migraine and nonmigrainous headaches was examined in two large cohorts from the Swedish Twin Registry consisting of 6448 (the older cohort) and 12 884 (the younger cohort) like-sexed twin pairs. Higher concordance rates were consistently found for lifetime migraine among the monozygotic twins than in the dizygotic twins. as well as for migraine headaches of the recurrent disabling type. In addition, a higher concordance rate was found among the monozygotic twins than in dizygotic twins in a ''mixed'' group of possible tension-type or mild migraine headaches (or both). The results of structural equation model-fitting analyses showed that genetic effects for migraine headaches were stronger for the females (estimates ranging from 49% to 58%) than for the males (39% to 44%) in the two cohorts. Unique nonshared environmental effects were greatest for the ''mixed'' group in both sexes (estimates ranging from 60% to 69%). The results are discussed in view of similar large-scale twin studies examining the heritability of liability to migraine.