Occlusal forces promote periodontal healing of transplanted teeth with enhanced nitric oxide synthesis.
Occlusal forces promote periodontal healing of transplanted teeth with enhanced nitric oxide synthesis.
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DOI：
10.11480/jmds.520108
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发表时间：
2005-03
影响因子：
--
通讯作者：
Chien-cheng Chen;Z. Kanno;K. Soma
中科院分区：
文献类型：
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作者：
Chien-cheng Chen;Z. Kanno;K. Soma
已有研究表明，咬合力可以促进移植牙的牙周愈合，预防牙槽骨强直，但其作用机制尚不清楚。由一氧化氮合酶（NOS）产生的一氧化氮（NO）被认为是参与创伤愈合的重要因素，并且随着机械刺激而增加。本研究旨在探讨咬合刺激、诱导型一氧化氮合酶（iNOS）与移植牙牙周膜愈合的关系。本研究使用5周龄Sprague-Dawley雄性大鼠。将大鼠右侧上颌第一磨牙再植后分为咬合组和非咬合组。在1周和2周后进行组织学观察。两周后，非闭塞组出现明显的关节强直和明显的PDL狭窄。另一方面，闭塞组显示PDL扩大和增厚，无关节强直。与非阻塞组相比，阻塞组样品中iNOS阳性细胞的数量显著增加。上述结果提示，咬合刺激促进了移植牙牙周膜愈合过程中NO的产生，可获得良好的效果。
It has been reported that occlusal forces promote periodontal healing of transplanted teeth and prevent dentoalveolar ankylosis, although its mechanism is still unclear. Nitric oxide (NO) produced by NO synthase (NOS) is considered to be an important factor which is involved in wound healing, and it increases with mechanical stimuli. The objective of this study was to examine the relationship among occlusal stimuli, inducible NOS (iNOS) and PDL healing of transplanted teeth. Five-week-old Sprague-Dawley male rats were used for this study. The right maxillary first molars of rats were replanted and animals were divided into occluded and non-occluded groups. Histologic observations were carried out after one and two weeks. After two weeks, the non-occluded group had clearly detectable ankylosis and obvious PDL stricture. On the other hand, the occluded group showed an enlarged and thickened PDL without ankylosis. The number of iNOS positive cells in the occluded group, samples significantly increased in comparison to that of the non-occluded group. These results suggest that occlusal stimuli enhanced the production of NO in the PDL healing process of transplanted teeth and a favorable result could be obtained.