Mouse major histocompatibility complex and lung development: haplotype variation, H-2 immunolocalization, and progressive maturation.
Mouse major histocompatibility complex and lung development: haplotype variation, H-2 immunolocalization, and progressive maturation.
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小鼠主要组织相容性复合体和肺发育：单倍型变异、H-2 免疫定位和渐进成熟。
DOI：
10.1002/ajmg.1320390413
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Melnick,M
中科院分区：
文献类型：
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作者：
Jaskoll,T;Hu,CC;Melnick,M
小鼠主要组织相容性复合体（H-2）、肺成熟和皮质类固醇反应性最近在先天性B10 （h - 2b）和B10中得到证实。A （h - 2a）小鼠（Hu et al.：美国医学遗传学杂志35:126-131,1990）。我们还研究了其他的单倍型[B10]。BR （h - 2k）和B10。D2 （H-2 d）证实H-2单倍型变异与肺成熟程度有很强的相关性。肺B10。D2, B10。BR， B10和B10。基因小鼠实现单倍型特异性成熟：B10。D2肺> B10肺= B10。BR肺> B10。一个肺。这些发育潜能的表达似乎受到皮质类固醇的调控。此外，为了验证H-2抗原在胚胎肺中用h - 2b （BIO）或h - 2k （B10）更早表达的假设。BR)单倍型比h - 2a （B10）高。A)单倍型，我们研究了H-2抗原在B10、B10中定位的时空格局。BR和B10。有和没有皮质激素治疗的基因小鼠品系。B10、B10中H-2抗原定位的空间格局相似。BR和B10。老鼠的肺；然而，这些模式在未治疗和治疗的B10和B10中出现得更早。与未处理的B10相比。A小鼠，提示H-2单倍型相关的肺成熟率。在皮质类固醇治疗后，所有同源菌株的H-2抗原在时间上具有可比性的空间分布。我们的研究结果提供了初步证据，表明肺“发育基因”和“糖皮质激素反应基因”很可能位于H-2复合物的KD亚区之外。讨论了H-2调节肺成熟和皮质类固醇反应的模型。
The association of the mouse major histocom-patibility complex (H-2), lung maturation, and corticosteroid responsiveness has recently been demonstrated in congenic B10 (H-2 b) and B10. A (H-2 a) mice (Hu et al.: American Journal of Medical Genetics 35: 126–131, 1990). We have investigated additional haplotypes [B10. BR (H-2 k) and B10. D2 (H-2 d] to confirm that there is a strong association between H-2 haplotype variation and the degree of pulmonary maturation. Lungs of B10. D2, B10. BR, B10, and B10. A congenic mice achieve haplotypic specific maturation: B10. D2 lungs> B10 lungs= B10. BR lung> B10. A lungs. It appears that the expression of these developmental potentials is under corticosteroid regulation. Further, to test the hypothesis that H-2 antigens would be expressed earlier in embryonic lungs with the H-2 b (BIO) or H-2 k (B10. BR) haplotype than with the H-2 a (B10. A) haplotype, we investigated the spatiotemporal patterns of H-2 antigen localization in B10, B10. BR, and B10. A congenic mouse strains with and without corticostroid treatment. The spatial patterns of H-2 antigen localization was similar in the B10, B10. BR, and B10. A mouse lungs; however, these patterns appeared earlier in both untreated and treated B10 and B10. BR mice as compared with untreated B10. A mice, suggesting an H-2 haplotype associated rate of pulmonary maturation. Following corticosteroid treatment, all congenic strains had a temporally comparable spatial distribution of H-2 antigens. Our results provide preliminary evidence suggesting that both a lung “developmental gene (s)” and a “glucocorticoid responsiveness gene (s)” are most likely outside the KD subregions of the H-2 complex. A model of the H-2 regulation of lung maturation and corticosteroid responsiveness is discussed.