Sex-related differences in sleep slow wave activity in major depressive disorder: a high-density EEG investigation.
Sex-related differences in sleep slow wave activity in major depressive disorder: a high-density EEG investigation.
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DOI：
10.1186/1471-244x-12-146
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发表时间：
2012-09-18
期刊：
影响因子：
4.4
通讯作者：
Benca RM
中科院分区：
文献类型：
--
作者：
Plante DT;Landsness EC;Peterson MJ;Goldstein MR;Riedner BA;Wanger T;Guokas JJ;Tononi G;Benca RM
睡眠障碍在重度抑郁障碍(MDD)中起着重要作用。先前的研究表明，MDD患者睡眠中的慢波活动(SWA)会发生改变；然而，不同研究的结果并不一致，部分原因可能是SWA的性别差异和/或频谱分析的空间分辨率有限。这项研究试图利用高密度脑电(HdEEG)来研究MDD患者大脑皮质中的SWA地形图，以及这种疾病中SWA地形图的性别相关变化。收集30例单相MDD患者(19例女性)和30例年龄、性别匹配的对照组的256个通道的整夜hdEEG记录。对SWA进行光谱分析，以确定组内差异。对MDD和对照组之间的SWA进行比较，包括按性别分层的分析，使用统计非参数图校正地形数据的多次比较。作为一个组，MDD受试者的整夜SWA显著增加，主要是在双侧前额叶通道。当按性别分层时，与年龄匹配的对照组相比，MDD女性的SWA总体上增加，这在双侧前额叶区域最为一致；然而，MDD男性与年龄匹配的对照组相比没有显著差异。进一步的分析表明，MDD妇女的SWA增加在夜间的前半部分最为明显。与对照受试者相比，患有MDD的女性，而不是男性，在多个皮质区域的SWA显著增加。有必要进一步研究SWA在MDD中的作用，并阐明MDD妇女SWA增加与疾病的病理生理学的关系。
Sleep disturbance plays an important role in major depressive disorder (MDD). Prior investigations have demonstrated that slow wave activity (SWA) during sleep is altered in MDD; however, results have not been consistent across studies, which may be due in part to sex-related differences in SWA and/or limited spatial resolution of spectral analyses. This study sought to characterize SWA in MDD utilizing high-density electroencephalography (hdEEG) to examine the topography of SWA across the cortex in MDD, as well as sex-related variation in SWA topography in the disorder. All-night recordings with 256 channel hdEEG were collected in 30 unipolar MDD subjects (19 women) and 30 age and sex-matched control subjects. Spectral analyses of SWA were performed to determine group differences. SWA was compared between MDD and controls, including analyses stratified by sex, using statistical non-parametric mapping to correct for multiple comparisons of topographic data. As a group, MDD subjects demonstrated significant increases in all-night SWA primarily in bilateral prefrontal channels. When stratified by sex, MDD women demonstrated global increases in SWA relative to age-matched controls that were most consistent in bilateral prefrontal regions; however, MDD men showed no significant differences relative to age-matched controls. Further analyses demonstrated increased SWA in MDD women was most prominent in the first portion of the night. Women, but not men with MDD demonstrate significant increases in SWA in multiple cortical areas relative to control subjects. Further research is warranted to investigate the role of SWA in MDD, and to clarify how increased SWA in women with MDD is related to the pathophysiology of the disorder.