Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
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DOI：
10.1016/j.bmc.2014.02.018
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发表时间：
2014-04-01
影响因子：
3.5
通讯作者：
Anderson AC
中科院分区：
文献类型：
--
作者：
Ononye SN;Vanheyst MD;Giardina C;Wright DL;Anderson AC
Thujaplicins are tropolone-derived natural products with antiproliferative properties. We recently reported that certain tropolones potently and selectively target histone deacetylases (HDAC) and inhibit the growth of hematological cell lines. Here, we investigated the mechanisms by which these compounds exert their antiproliferative activity in comparison with the pan-selective HDAC inhibitor, vorinostat, using Jurkat T-cell leukemia cells. The tropolones appear to work through a mechanism distinct from vorinostat. These studies suggest that tropolone derivatives may serve as selective epigenetic modulators of hematological cells with potential applications as anti-leukemic or anti-inflammatory agents.
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影响因子：
4.2
作者：
Ononye, Sophia N.;VanHeyst, Michael D.;Wright, Dennis L.
通讯作者：
Wright, Dennis L.
影响因子：
5.1
作者：
Ji, Mu-huo;Li, Guo-min;Yang, Jian-jun
通讯作者：
Yang, Jian-jun
影响因子：
6.5
作者：
Murakami, Takashi;Sato, Atsuko;Kobayashi, Eiji
通讯作者：
Kobayashi, Eiji
影响因子：
4.4
作者：
Palmer, DC;Balasubramaniam, S;Restifo, NP
通讯作者：
Restifo, NP
影响因子：
2.2
作者：
Smolewski, P;Grabarek, J;Darzynkiewicz, Z
通讯作者：
Darzynkiewicz, Z