Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses
Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses
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DOI：
10.1016/j.nuclcard.2006.08.016
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发表时间：
2006-11-01
影响因子：
2.4
通讯作者：
Glover, David K.
中科院分区：
文献类型：
--
作者：
Hatada, Kengo;Ruiz, Mirta;Glover, David K.
背景资料。~(99m)Tc-N-DBODC5是一种新的心肌灌注示踪剂，在正常大鼠体内表现出较高的心脏摄取和快速的肝脏清除能力。本研究的目的是(1)在临床相关的大型动物物种中比较~(99m)Tc-N-DBODC5和~(99m)Tl-DBODC5在3小时内的器官生物分布和心肌摄取、清除和再分布动力学；(2)比较在冠状动脉狭窄犬血管扩张剂应激期间联合注射~(99)m N-DBODC5和Tl 201的心肌摄取。在腺苷诱导的充血高峰期，10只严重左前降支狭窄的犬接受了TC-99mN-DBODC5(n=6)或TC-99m Sestamibi(n=4)和微球，随后进行了连续成像和3小时的采血。另14只犬左前降支重度狭窄(n=7)或轻度狭窄(n=7)，在扩张剂负荷高峰时同时注射99mTcN-DBODC5、TI-201和微球。与Sestamibi相似，Tc99mNDBODC5表现出良好的心肌摄取，洗出缓慢，在3小时内几乎没有再分布(P=0.0 5)；然而，Tc99mN-DBODC5从肝脏清除更快(30分钟心肺比，0.92+/-0.11比0.51+/-0.05；P<；0.05)。在充血状态下注射时，Tc99mNDBODC5的心肌提取平台低于TI201，介于Tc99mSestamibi和Tc99mTg之间。良好的器官生物分布、心肌摄取和清除动力学特性，结合快速的肝脏清除和良好的如何提取关系，使TC-99mN-DBODC5成为一种非常有前途的新的心肌灌注显像剂。
Background. Technetium 99m N-DBODC5 is a new myocardial perfusion tracer shown to exhibit high heart uptake and rapid liver clearance in normal rats. The objectives of this canine study were (1) to compare the organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 with Tc-99m sestamibi over a period of 3 hours in a more clinically relevant large animal species and (2) to compare the myocardial uptake of Tc-99m N-DBODC5 with thallium 201 when co-injected during vasodilator stress in dogs with coronary stenoses.Methods and Results. At peak adenosine-induced hyperemia, 10 dogs with critical left anterior descending artery stenoses received either Tc-99m N-DBODC5 (n = 6) or Tc-99m sestamibi (n = 4) and microspheres, followed by serial imaging and blood sampling over a period of 3 hours. Another 14 dogs with either critical (n = 7) or mild (n = 7) left anterior descending artery stenoses underwent simultaneous injection of Tc-99m N-DBODC5, TI-201, and microspheres during peak vasodilator stress. Like sestamibi, Tc-99m NDBODC5 showed good myocardial uptake with slow washout and minimal redistribution over a period of 3 hours (P = not significant); however, Tc-99m N-DBODC5 cleared more rapidly from the liver (heart-lung ratio at 30 minutes, 0.92 +/- 0.11 versus 0.51 +/- 0.05; P < .05). When injected during hyperemic flow, the myocardial extraction plateau for Tc-99m NDBODC5 was lower than that for TI-201 and was intermediate between Tc-99m sestamibi and Tc-99m tetrofosmin.Conclusions. Excellent organ biodistribution and myocardial uptake and clearance kinetic properties, combined with rapid liver clearance and a favorable How-extraction relationship, make Tc-99m N-DBODC5 a very promising new myocardial perfusion imaging agent.