Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: a case report.
Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: a case report.
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DOI：
10.1186/s13027-016-0051-3
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发表时间：
2016
影响因子：
3.7
通讯作者：
Calabrò ML
中科院分区：
文献类型：
--
作者：
Cattelan AM;Mattiolo A;Grassi A;Piano MA;Sasset L;Trevenzoli M;Zanovello P;Calabrò ML
我们在这里提出的情况下，免疫重建炎症综合征与卡波西肉瘤（KS-IRIS）开发的艾滋病患者开始抗逆转录病毒治疗（ART）后两个月。在12例初治AIDS-KS患者的队列中，分析了该IRIS-KS病例的基线特征。CD 4细胞计数、血浆HIV RNA载量、KS临床分期、人疱疹病毒8型（HHV 8）抗体滴度和外周血单核细胞和唾液中HHV 8载量无统计学显著差异。发现KS-IRIS患者血浆中的HHV 8载量显著高于11名KS消退患者（> 6 log 10基因组当量/ml，p = 0.01，t检验）。该病例强调，血浆中HHV 8载量的测量可能有助于识别具有KS-IRIS风险的患者，并且该参数应纳入大型研究的设计中，以定义KS-IRIS风险预测因子。
We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t–test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.