Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles.
Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles.
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甲苯咪唑作为乙烯信号激活剂的鉴定揭示了乙烯信号在侧根角度调节中的作用。
DOI：
10.1016/j.celrep.2024.113763
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发表时间：
2024
期刊：
影响因子：
8.8
通讯作者：
Busch,Wolfgang
中科院分区：
文献类型：
--
作者：
He,Wenrong;Truong,HaiAn;Zhang,Ling;Cao,Min;Arakawa,Neal;Xiao,Yao;Zhong,Kaizhen;Hou,Yingnan;Busch,Wolfgang
侧根角（GSA）是决定根系径向扩展的一个重要的根系构型特征。因此，GSA对植物获取土壤中营养和水分的能力起着至关重要的作用。只有少数调控途径和机制，确定GSA是已知的。这些主要涉及生长素和细胞分裂素途径。在这里，我们报告了一个小分子，甲苯咪唑（MBZ），调节GSA在拟南芥根和行动，通过激活乙烯信号。MBZ直接作用于丝氨酸/苏氨酸蛋白激酶CTR 1，其是乙烯信号传导的负调节剂。我们的研究不仅表明，乙烯信号通路是必不可少的GSA调节，但也确定了RSA的小分子调节剂，乙烯受体的下游作用，并直接激活乙烯信号。
The lateral root angle or gravitropic set-point angle (GSA) is an important trait for root system architecture (RSA) that determines the radial expansion of the root system. The GSA therefore plays a crucial role for the ability of plants to access nutrients and water in the soil. Only a few regulatory pathways and mechanisms that determine GSA are known. These mostly relate to auxin and cytokinin pathways. Here, we report the identification of a small molecule, mebendazole (MBZ), that modulates GSA inArabidopsis thalianaroots and acts via the activation of ethylene signaling. MBZ directly acts on the serine/threonine protein kinase CTR1, which is a negative regulator of ethylene signaling. Our study not only shows that the ethylene signaling pathway is essential for GSA regulation but also identifies a small molecular modulator of RSA that acts downstream of ethylene receptors and that directly activates ethylene signaling.