Clinical significance of Smac/DIABLO expression in colorectal cancer
Clinical significance of Smac/DIABLO expression in colorectal cancer
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DOI：
10.3892/or_00000229
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发表时间：
2009-02-01
期刊：
影响因子：
4.2
通讯作者：
Maehara, Yoshihiko
中科院分区：
文献类型：
--
作者：
Endo, Kazuya;Kohnoe, Shunji;Maehara, Yoshihiko
第二种来源于线粒体的半胱天冬酶激活剂/具有低PI的凋亡结合蛋白的直接抑制剂（Smac/DIABLO）响应于凋亡刺激而由线粒体释放，并且被认为通过拮抗凋亡蛋白的抑制剂来调节凋亡，所述凋亡蛋白在癌细胞对各种治疗方案的敏感性中起重要作用。Smac/DIABLO的表达已在多种癌细胞中得到证实，但其在结直肠癌中的临床意义知之甚少。本研究旨在通过对结直肠癌患者的临床病理分析，探讨Smac/DIABLO表达与结直肠癌患者预后的关系。采用免疫组化方法检测121例结直肠癌组织中Smac/DIABLO的表达，并分析其与临床病理因素的关系。Smac/DIABLO阳性表达率为66%（80/121）。Smac/DIABLO阴性组的淋巴结转移率和远处转移率明显高于Smac/DIABLO阳性组（P=0.0004和P=0.003）。单因素分析显示，Smac/DIABLO阴性表达患者的生存率明显低于Smac/DIABLO阳性表达患者（P
Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low PI (Smac/DIABLO) is released by mitochondria in response to apoptotic stimuli and is thought to regulate apoptosis by antagonizing inhibitors of apoptosis proteins, which play an important role in sensitization of cancer cells to various therapeutic regimens. The expression of Smac/DIABLO has been demonstrated in various cancer cells, though little is known about its clinical significance with respect to colorectal cancer. The current study was designed to evaluate the relationship between prognosis and Smac/DIABLO expression by clinicopathological analysis of patients with colorectal cancer. Smac/DIABLO expression was evaluated using immunohistochemical staining in 121 consecutive patients with colorectal cancer and the relationship between Smac/DIABLO expression and clinicopathological factors was analyzed. Smac/DIABLO-positive expression was detected in 80 of the 121 patients (66%). The incidence of lymph node and distant metastasis in Smac/DIABLO-negative cancer was significantly higher than that in Smac/DIABLO-positive cancer (P=0.0004 and P=0.003, respectively). While univariate analysis showed that survival in patients with Smac/DIABLO-negative expression was significantly poorer than in Smac/DIABLO-positive cases (P