Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis
Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis
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DOI：
10.1126/science.1200940
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发表时间：
2011-07-15
期刊：
影响因子：
56.9
通讯作者：
Matsuno, Kenji
中科院分区：
文献类型：
--
作者：
Taniguchi, Kiichiro;Maeda, Reo;Matsuno, Kenji
动物的一些器官显示左右（LR）不对称。为了更好地了解果蝇LR不对称形态发生，我们研究了后肠上皮管的LR定向旋转。后肠上皮细胞在其平面内采用LR不对称（手性）细胞形状，我们将这种细胞行为称为平面细胞形状手性（PCC）。果蝇E-cadherin（DE-Cad）分布于细胞边界，具有LR不对称性，是PCC形成的主要原因。肌球蛋白ID切换PCC和DE-Cad分布中发现的LR极性，这与旋转方向一致。计算机模拟显示PCC足以诱导该组织的定向旋转。因此，上皮细胞在体内的内在手性是LR不对称组织形态发生的潜在机制。
Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of the hindgut epithelial tube. Hindgut epithelial cells adopt a LR asymmetric (chiral) cell shape within their plane, and we refer to this cell behavior as planar cell-shape chirality (PCC). Drosophila E-cadherin (DE-Cad) is distributed to cell boundaries with LR asymmetry, which is responsible for the PCC formation. Myosin ID switches the LR polarity found in PCC and in DE-Cad distribution, which coincides with the direction of rotation. An in silico simulation showed that PCC is sufficient to induce the directional rotation of this tissue. Thus, the intrinsic chirality of epithelial cells in vivo is an underlying mechanism for LR asymmetric tissue morphogenesis.