Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women
Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women
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DOI：
10.1097/gme.0b013e31824ac071
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Iwaniec, Urszula T.
中科院分区：
文献类型：
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作者：
Marrone, Jill A.;Maddalozzo, Gianni F.;Iwaniec, Urszula T.
目的：流行病学研究表明绝经后妇女骨量增加与适度饮酒有关。然而，负责酒精对骨的假定有益作用的潜在细胞机制尚不清楚。过度的骨转换，结合骨吸收超过骨形成的不平衡，是绝经后骨丢失的主要原因。本研究探讨了这一假设，适度的酒精摄入量衰减绝经后骨turnover after menopaus.Methods：骨密度测定双能X射线吸收法在40名健康绝经后妇女（平均+/- SE年龄，56.3 +/- 0.5年）谁消耗酒精在19 +/- 1克/天。在基线（第0天）和戒酒14天后，通过免疫测定法测定骨形成标志物骨钙素和骨吸收标志物C末端肽（CTx）的血清水平。结果：股骨粗隆和全髋的骨密度与饮酒水平呈正相关。戒断后血清骨钙素和CTx升高（与基线相比，分别为4.1 ± 1.6%，P = 0.01和5.8 ± 2.6%，P = 0.02）。骨钙素和CTx在酒精再给药后较前一天下降，（分别为-3.4 +/-1.4%，P = 0.01和-3.5 +/-2.1%，P = 0.05），至与基线无差异的值结论：戒酒后骨转换指标升高，而恢复饮酒后骨转换指标降低。这些结果表明，绝经后适度饮酒者骨密度增加的细胞机制。具体而言，酒精对骨转换的抑制作用减弱了与绝经相关的过度骨转换对骨骼的有害影响。
Objective: Epidemiological studies indicate that higher bone mass is associated with moderate alcohol consumption in postmenopausal women. However, the underlying cellular mechanisms responsible for the putative beneficial effects of alcohol on bone are unknown. Excessive bone turnover, combined with an imbalance whereby bone resorption exceeds bone formation, is the principal cause of postmenopausal bone loss. This study investigated the hypothesis that moderate alcohol intake attenuates bone turnover after menopause.Methods: Bone mineral density was determined by dual-energy x-ray absorptiometry in 40 healthy postmenopausal women (mean +/- SE age, 56.3 +/- 0.5 y) who consumed alcohol at 19 +/- 1 g/day. Serum levels of the bone formation marker osteocalcin and the resorption marker C-terminal telopeptide (CTx) were measured by immunoassay at baseline (day 0) and after alcohol withdrawal for 14 days. Participants then consumed alcohol and were assayed on the following morning.Results: Bone mineral density at the trochanter and total hip were positively correlated to the level of alcohol consumption. Serum osteocalcin and CTx increased after abstinence (4.1 +/- 1.6%, P = 0.01 and 5.8 +/- 2.6%, P = 0.02 compared with baseline, respectively). Osteocalcin and CTx decreased after alcohol readministration, compared with the previous day (-3.4 +/- 1.4%, P = 0.01 and -3.5 +/- 2.1%, P = 0.05, respectively), to values that did not differ from baseline (P > 0.05).Conclusions: Abstinence from alcohol results in increased markers of bone turnover, whereas resumption of alcohol reduces bone turnover markers. These results suggest a cellular mechanism for the increased bone density observed in postmenopausal moderate alcohol consumers. Specifically, the inhibitory effect of alcohol on bone turnover attenuates the detrimental skeletal consequences of excessive bone turnover associated with menopause.