Extracellular Matrix Molecules, their Receptors, and Secreted Proteases in Synaptic Plasticity
Extracellular Matrix Molecules, their Receptors, and Secreted Proteases in Synaptic Plasticity
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DOI：
10.1002/dneu.20958
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发表时间：
2011-11-01
影响因子：
3
通讯作者：
Dityatev, Alexander
中科院分区：
文献类型：
--
作者：
Wlodarczyk, Jakub;Mukhina, Irina;Dityatev, Alexander
神经细胞分泌多种分子，这些分子在细胞外空间积聚并形成细胞外基质（ECM）。人们普遍认为细胞和 ECM 之间的相互作用在细胞迁移和轴突生长引导中发挥着至关重要的作用，而以神经元周围网形式形成的成熟神经 ECM 被认为限制了某些形式的发育可塑性。另一方面，神经周围网络和其他 ECM 分子的主要成分支持功能可塑性的诱导，其中研究最多的形式是长时程增强。在这里，我们回顾了 ECM 分子、其受体和重塑蛋白酶调节突触修饰的诱导和维持的潜在机制。我们特别强调，蛋白酶的活性依赖性分泌和激活导致 ECM 的局部裂解和信号蛋白水解片段的释放。这些分子调节递质受体的运输、肌动蛋白细胞骨架、树突棘的生长和树突丝状伪足的形成。 (C) 2011 Wiley periodicals, Inc. 开发 Neurobiol 71: 1040-1053, 2011
Neural cells secrete diverse molecules, which accumulate in the extracellular space and form the extracellular matrix (ECM). Interactions between cells and the ECM are well recognized to play the crucial role in cell migration and guidance of growing axons, whereas formation of mature neural ECM in the form of perineuronal nets is believed to restrict certain forms of developmental plasticity. On the other hand, major components of perineuronal nets and other ECM molecules support induction of functional plasticity, the most studied form of which is long-term potentiation. Here, we review the underlying mechanisms by which ECM molecules, their receptors and remodeling proteases regulate the induction and maintenance of synaptic modifications. In particular, we highlight that activity-dependent secretion and activation of proteases leads to a local cleavage of the ECM and release of signaling proteolytic fragments. These molecules regulate transmitter receptor trafficking, actin cytoskeleton, growth of dendritic spines, and formation of dendritic filopodia. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1040-1053, 2011