Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis
Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis
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脂溢性角化病所致基底细胞癌二例
DOI：
10.1111/j.1346-8138.1997.tb02798.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
S. Kon
中科院分区：
文献类型：
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作者：
T. Akasaka;S. Kon
本文报告两例基底细胞癌发生在脂溢性角化病。第一个病例是一名73岁的女性，她的胸部有一个由色素沉着病变引起的黑色结节。结节和色素性病变的组织学分析显示，基底细胞癌与毛囊分化和棘皮症脂溢性角化病，分别。第二个病例是一名70岁的女性，背部有一个色素性病变引起的黑色结节。结节的组织学分析显示一个不典型的基底样细胞团周围的脂溢性角化病病变。除了与基底细胞癌共存的脂溢性角化病外，还发现了基底样毛囊错构瘤，其显示多个错构瘤毛囊或小囊肿被纤维血管间质包围的基底样细胞的分支索或花边样网络所取代。我们的结论是，这两个案件提出了一个罕见的组合，脂溢性角化病经历了恶性变化的基底细胞癌。基底细胞癌和脂溢性角化病可能来源相似：表皮或毛囊上皮的多能细胞。
The present study reports two cases of basal cell carcinoma arising in seborrheic keratosis. The first case is a seventy‐three‐year‐old female who presented with a blackish nodule arising from a pigmented lesion on her chest. Histopathological analysis of the nodule and the pigmented lesion revealed a basal cell carcinoma with hair follicular differentiation and an acanthotic seborrheic keratosis, respectively. The second case is a seventy‐year‐old female with a blackish nodule arising from a pigmented lesion on her back. Histological analysis of the nodule revealed an atypical basaloid cell mass surrounded by a seborrheic keratosis lesion. In addition to the coexisting seborrheic keratosis with the basal cell carcinoma, a basaloid follicular hamartoma that showed muliple hamartomatous hair follicles or small cysts replaced by a branching cord or lace‐like network of basaloid cells surrounded by fibrovascular stroma was identified. We concluded that both cases presented a rare combination of a seborrheic keratosis which underwent a malignant change to basal cell carcinoma. It appears that both basal cell carcinomas and seborrheic keratosis may derive from a similar source: pluripotential cells of either the epidermis or hair follicle epithelium.