Inherited disorders of ion transport in the intestine
Inherited disorders of ion transport in the intestine
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DOI：
10.1016/s0959-437x(00)00088-5
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发表时间：
2000-06-01
影响因子：
4
通讯作者：
Höglund, P
中科院分区：
文献类型：
--
作者：
Kere, J;Höglund, P
在过去的一年中，已经确定在人类先天性氯腹泻疾病中突变的基因编码肠道上皮细胞顶膜处的主要Cl-/HCO 3-交换器。一个主要的顶端Na+/H+交换也已确定。人们对金属离子吸收有了新的认识，并克隆了几种没有相关疾病的新转运蛋白。
Within the past year, it has been established that the gene mutated in the human disorder congenital chloride diarrhea encodes a major Cl-/HCO3- exchanger at the apical membrane of gut epithelial cells. A major apical Na+/H+ exchanger has also been identified. New insight into metal ion absorption has been gained, and several new transporters without cognate diseases have been cloned.