Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium
Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium
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DOI：
10.1016/j.ijpara.2007.10.002
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发表时间：
2008-02-01
影响因子：
4
通讯作者：
Pemberton, Alan D.
中科院分区：
文献类型：
--
作者：
Brown, Jeremy K.;Knight, Pamela A.;Pemberton, Alan D.
Phospholipase A(2) (PLA(2)) enzymes play a central role in the initiation, propagation and resolution of inflammation. Here, we describe de novo expression of group IVC PLA(2) (PLA2g4c) within the intestinal epithelium of Trichinella spiralis parasitised mice. This mouse mast cell protease-1 sensitive, calcium-independent PLA2 is not detectable in the jejunal epithelium of uninfected mice but becomes highly expressed within the epithelial compartment within days of nematode establishment. We propose that epithelial PLA2g4c accounts for the increased lysophospholipase activity observed during intestinal nematodiasis and that it plays a major role in the inflammatory response to nematodes. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
