Prostaglandin E2 and alpha 2 adrenoceptor agonists inhibit the pentose phosphate shunt in pancreatic islets.
Prostaglandin E2 and alpha 2 adrenoceptor agonists inhibit the pentose phosphate shunt in pancreatic islets.
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DOI：
10.1016/0003-9861(89)90117-3
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发表时间：
1989-02
影响因子：
3.9
通讯作者：
S. G. Laychock
中科院分区：
文献类型：
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作者：
S. G. Laychock
前列腺素(PG)E2和α-2肾上腺素受体激动剂可乐定对大鼠胰岛葡萄糖利用的抑制作用相似，其他前列腺素不影响葡萄糖利用。[1-14C]葡萄糖和[6-14C]葡萄糖的胰岛氧化反应表明，前列腺素E_2和可乐定抑制了戊糖磷酸分流。百日咳毒素拮抗可乐定和前列腺素E_2对总葡萄糖利用率和磷酸戊糖分流活性的影响。结果提示，PGE_2和α_2受体激动剂可能通过相似的转导机制调节糖代谢，鸟嘌呤核苷酸结合调节(G)蛋白调节前列腺素和肾上腺素能激动剂的某些代谢效应。
Glucose utilization in isolated pancreatic islets of the rat was inhibited by prostaglandin (PG) E2and theα2adrenoceptor agonist, clonidine, to a similar extent; other prostaglandins did not affect glucose utilization. Islet oxidation of [1-14C]glucose and [6-14C]glucose demonstrated that the pentose phosphate shunt was inhibited by PGE2and clonidine. Pertussis toxin antagonizes the effects of clonidine and PGE2on total glucose utilization and pentose phosphate shunt activity. The results suggest that PGE2andα2adrenoceptor agonists may regulate glucose metabolism through similar transduction mechanisms, and that a guanine nucleotide binding regulatory (G) protein modulates certain metabolic effects of prostaglandins and adrenergic agonists.