Electrophysiological properties of neurons in guinea pig bronchial parasympathetic ganglia.
Electrophysiological properties of neurons in guinea pig bronchial parasympathetic ganglia.
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DOI：
10.1152/ajplung.1990.259.6.l403
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发表时间：
1990-12
期刊：
影响因子：
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通讯作者：
Allen C. Myers;B. J. Undem;Daniel Weinreich
中科院分区：
文献类型：
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作者：
Allen C. Myers;B. J. Undem;Daniel Weinreich
在豚鼠右支气管上新定位的神经节中，体外检查了副交感神经元的主动和被动膜特性。根据神经元对阈上去极化恒定电流步骤的动作电位放电响应，神经元可以分为“强直性”或“阶段性”。强直神经元 (39%) 在整个当前步骤中以持续的重复动作电位做出反应，而相位神经元 (61%) 在步骤开始时以动作电位的初始爆发做出反应，但随后进行了调节。强直性和相位性神经元无法通过其他主动或被动膜特性来区分。迷走神经的电刺激引起一到三个时间上不同的快速烟碱兴奋电位，迷走神经的强直刺激引起缓慢去极化（10％的神经元）和超极化（25％的神经元）电位；后者是通过毒蕈碱受体激活来模拟的。在强直和相位神经元中观察到类似的慢速和快速突触后电位。我们认为支气管神经节内的神经元具有能够整合突触前刺激的膜和突触特性。
Active and passive membrane membrane properties of parasympathetic neurons were examined in vitro in a newly localized ganglion on the right bronchus of the guinea pig. Neurons could be classified as "tonic" or "phasic" based on their action potential discharge response to suprathreshold depolarizing constant current steps. Tonic neurons (39%) responded with repetitive action potentials sustained throughout the current step, whereas phasic neurons (61%) responded with an initial burst of action potentials at the onset of the step but then accommodated. Tonic and phasic neurons could not be differentiated by other active or passive membrane properties. Electrical stimulation of the vagus nerve elicited one to three temporally distinct fast nicotinic excitatory potentials, and tetanic stimulation of the vagus nerve evoked slow depolarizing (10% of neurons) and hyperpolarizing (25% of neurons) potentials; the latter was mimicked by muscarinic receptor activation. Similar slow and fast postsynaptic potentials were observed in both tonic and phasic neurons. We suggest neurons within the bronchial ganglion possess membrane and synaptic properties capable of integrating presynaptic stimuli.