Patterns of bone metastases in newly diagnosed colorectal cancer: a real-world analysis in the SEER database
Patterns of bone metastases in newly diagnosed colorectal cancer: a real-world analysis in the SEER database
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新诊断结直肠癌的骨转移模式：SEER 数据库中的真实世界分析
DOI：
10.1007/s00384-018-3213-5
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发表时间：
2019-03-01
影响因子：
2.8
通讯作者：
Wang, Xin
中科院分区：
文献类型：
--
作者：
Guo, Xu;Zhang, Chao;Wang, Xin
目的采用监测、流行病学和最终结果（SEER）队列研究方法，对2010 - 2015年初治结直肠癌（CRC）患者的骨转移发生率及其影响因素进行分析。对随访1年以上的患者进行BM预后因素分析。结果共纳入212,787例符合条件的结直肠癌患者，其中2557例（1.20%）被诊断为原发性BM。直肠癌的BM发病率显著高于左右结肠癌（2 =107.64，P
Purpose To investigate the incidence and the associated factors for bone metastases (BM) development and prognosis in initial colorectal cancer (CRC) with a large sample using Surveillance, Epidemiology, and End Results (SEER) cohort.Methods Primary CRC patients, who were initially diagnosed between 2010 and 2015 in the SEER database, were included to analyze BM incidence and risk factors for BM occurrence. The patients with at least 1-year follow-up were involved to investigate the prognostic factors for BM. Multivariable logistic and proportional hazard regression models were used to investigate the risk factors for BM development and prognosis, respectively.Results A total of 212,787 eligible CRC patients were included and 2557 of them were diagnosed with de novo BM (1.20%). Rectal cancer presented significantly higher BM incidence than right and left colon cancer ((2)=107.64, P