Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and-3 suppress the induction and progression of murine allergic conjunctivitis
Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and-3 suppress the induction and progression of murine allergic conjunctivitis
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DOI：
10.1016/j.bbrc.2006.12.023
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发表时间：
2007-02-02
影响因子：
3.1
通讯作者：
Ueno, Hisayuki
中科院分区：
文献类型：
--
作者：
Fukushima, Atsuki;Sumi, Tamaki;Ueno, Hisayuki
T细胞IG和含粘蛋白结构域的蛋白（Tim）调节Th 1和Th 2介导的免疫应答。我们研究了阻断Tim-1或Tim-3配体结合活性的Ab预防和治疗小鼠实验性过敏性结膜炎（EC）（一种Th 2介导的疾病）的能力。在主动免疫的野生型小鼠中，在EC的诱导阶段用任一种Ab治疗抑制EC并上调Th 1和Th 2免疫应答。相反，两种抗体在主动免疫的IFN-γ敲除小鼠中加重EC。因此，两种抗Tim Ab通过上调全身IFN-γ产生来抑制诱导期产生的致病性免疫应答。主动免疫的小鼠和被动免疫的小鼠在RW攻击前用抗Tim Ab治疗也抑制了EC。因此，用抗Tim-1或抗Tim-3 Ab治疗可以抑制EC的诱导和进展，这可能指示过敏性疾病如过敏性结膜炎的潜在预防和/或治疗方法。(c)2006爱思唯尔公司All rights reserved.
The T cell Ig and mucin domain-containing proteins (Tim) regulate Th1- and Th2-mediated immune responses. We investigated the ability of Abs blocking Tim-1 or Tim-3 ligand-binding activity to prevent and treat murine experimental allergic conjunctivitis (EC), a Th2-mediated disease. Treatment with either Ab during the induction phase of EC in actively immunized wild-type mice suppressed EC and upregulated Th1 and Th2 immune responses. In contrast, both Abs exacerbated EC in actively immunized IFN-gamma-knockout mice. Thus, both anti-Tim Abs suppress the pathogenic immune responses generated in the induction phase by upregulating systemic IFN-gamma production. Treatment of actively immunized mice and passively immunized mice with either anti-Tim Ab just prior to RW challenge also suppressed EC. Thus, treatment with anti-Tim-1 or anti-Tim-3 Ab can suppress both the induction and progression of EC, which could indicate potential preventive and/or therapeutic approaches for allergic diseases such as allergic conjunctivitis. (c) 2006 Elsevier Inc. All rights reserved.